Adrian Whitty: search on Z-Library

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1

The resurgence of covalent drugs

Singh, Juswinder, Petter, Russell C., Baillie, Thomas A., Whitty, Adrian

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

2

Cyberspace as Potential Space: Considering the Web as a Playground to Cyber-Flirt

Whitty, Monica T., Carr, Adrian N.

Journal:

Human Relations

Year:

2003

Language:

english

File:

PDF, 101 KB

english, 2003

3

How proteins bind macrocycles

Villar, Elizabeth A, Beglov, Dmitri, Chennamadhavuni, Spandan, Porco, John A, Kozakov, Dima, Vajda, Sandor, Whitty, Adrian

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.61 MB

english, 2014

4

Taking the Good with the Bad

Whitty, Monica T., Carr, Adrian N.

Journal:

Journal of Couple & Relationship Therapy

Year:

2005

Language:

english

File:

PDF, 625 KB

english, 2005

5

Doing transformational change in the English NHS in the context of “big bang” redisorganisation

Hunter, David J., Erskine, Jonathan, Small, Adrian, McGovern, Tom, Hicks, Chris, Whitty, Paula, Lugsden, Edward

Journal:

Journal of Health Organisation and Management

Year:

2015

Language:

english

File:

PDF, 336 KB

english, 2015

6

Wet season flood magnitude drives resilience to dry season drought of a euryhaline elasmobranch in a dry-land river

Lear, Karissa O., Morgan, David L., Whitty, Jeff M., Beatty, Stephen J., Gleiss, Adrian C.

Journal:

Science of The Total Environment

Year:

2021

File:

PDF, 3.52 MB

2021

7

New rules in the workplace: Applying object-relations theory to explain problem Internet and email behaviour in the workplace

Monica T. Whitty, Adrian N. Carr

Journal:

Computers in Human Behavior

Year:

2006

Language:

english

File:

PDF, 244 KB

english, 2006

8

Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-β (IFN-β)

Laura Runkel, Werner Meier, R. Blake Pepinsky, Michael Karpusas, Adrian Whitty, Kathleen Kimball, Margot Brickelmaier, Celine Muldowney, Wendy Jones, Susan E. Goelz

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 1.35 MB

1998

9

Subtilisin Enzymes: Practical Protein Engineering.by Richard Bott; Christian Betzel

Review by: Adrian Whitty

Journal:

Quarterly Review of Biology

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

10

10.1038/ni737

Bromley, Shannon K., Iaboni, Andrea, Davis, Simon J., Whitty, Adrian, Green, Jonathan M., Shaw, Andrey S., Weiss, Arthur, Dustin, Michael L.

Journal:

Nature Immunology

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

11

Low affinity binding of an LFA-3/IgG1 fusion protein to CD2 + T cells is independent of cell activation

Majeau, Gerard R., Whitty, Adrian, Yim, Kalvin, Meier, Werner, Hochman, Paula S.

Journal:

Cell Communication and Adhesion

Year:

1999

Language:

english

File:

PDF, 1.04 MB

english, 1999

12

Are vertical migrations driven by circadian behaviour? Decoupling of activity and depth use in a large riverine elasmobranch, the freshwater sawfish (Pristis pristis)

Gleiss, Adrian C., Morgan, David L., Whitty, Jeff M., Keleher, James J., Fossette, Sabrina, Hays, Graeme C.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.72 MB

english, 2017

13

Editorial overview: Next generation therapeutics

Whitty, Adrian, Tonge, Peter J

Journal:

Current Opinion in Chemical Biology

Year:

2018

Language:

english

File:

PDF, 140 KB

english, 2018

14

Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification

Taylor, Frederick R., Wen, Dingyi, Garber, Ellen A., Carmillo, Amie N., Baker, Darren P., Arduini, Robert M., Williams, Kevin P., Weinreb, Paul H., Rayhorn, Paul, Hronowski, Xiaoping, Whitty, Adrian,

Journal:

Year:

2001

Language:

english

File:

PDF, 254 KB

english, 2001

15

Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)

Zhou, Li, Yeo, Alan T., Ballarano, Carmine, Weber, Urs, Allen, Karen N., Gilmore, Thomas D., Whitty, Adrian

Journal:

Year:

2014

Language:

english

File:

PDF, 5.28 MB

english, 2014

16

Cryptic binding sites on proteins: definition, detection, and druggability

Vajda, Sandor, Beglov, Dmitri, Wakefield, Amanda E, Egbert, Megan, Whitty, Adrian

Journal:

Current Opinion in Chemical Biology

Year:

2018

Language:

english

File:

PDF, 969 KB

english, 2018

17

Recruitment of a critically endangered sawfish into a riverine nursery depends on natural flow regimes

Lear, Karissa O., Gleiss, Adrian C., Whitty, Jeff M., Fazeldean, Travis, Albert, J. R., Green, Nathan, Ebner, Brendan C., Thorburn, Dean C., Beatty, Stephen J., Morgan, David L.

Journal:

Scientific Reports

Year:

2019

File:

PDF, 3.13 MB

2019

18

Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers

Alasdair F Bell, Yuguo Feng, Hilary A Hofstein, Sapan Parikh, Jiaquan Wu, Michael J Rudolph, Caroline Kisker, Adrian Whitty, Peter J Tonge

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 186 KB

english, 2002

19

A Central Region of NEMO is Required for IKKβ-Induced Conformational Change and for Signal Propagation

Shaffer, Robert, DeMaria, Anthony H., Kagermazova, Larisa, Liu, Yuekun, Babaei, Milad, Penix, Suhaily, Cervantes, Arisdelsy, Jehle, Stefan, Makowski, Lee, Gilmore, Thomas D., Whitty, Adrian, Allen, Ka

Journal:

Year:

2019

Language:

english

File:

PDF, 4.74 MB

english, 2019

20

Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret

Schlee, Sandra, Carmillo, Paul, Whitty, Adrian

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 358 KB

english, 2006

21

Quantification and Modeling of Tripartite CD2-, CD58FC Chimera (Alefacept)-, and CD16-mediated Cell Adhesion

Dustin, Michael L., Starr, Toby, Coombs, Daniel, Majeau, Gerard R., Meier, Werner, Hochman, Paula S., Douglass, Adam, Vale, Ron, Goldstein, Byron, Whitty, Adrian

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 633 KB

english, 2007

22

Ligand deconstruction: Why some fragment binding positions are conserved and others are not

Kozakov, Dima, Hall, David R., Jehle, Stefan, Luo, Lingqi, Ochiana, Stefan O., Jones, Elizabeth V., Pollastri, Michael, Allen, Karen N., Whitty, Adrian, Vajda, Sandor

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1003 KB

english, 2015

23

Structural conservation of druggable hot spots in protein–protein interfaces

Dima Kozakov, David R. Hall, Gwo-Yu Chuang, Regina Cencic, Ryan Brenke, Laurie E. Grove, Dmitri Beglov, Jerry Pelletier, Adrian Whitty and Sandor Vajda

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

24

Divergent field metabolic rates highlight the challenges of increasing temperatures and energy limitation in aquatic ectotherms

Lear, Karissa O., Morgan, David L., Whitty, Jeff M., Whitney, Nicholas M., Byrnes, Evan E., Beatty, Stephen J., Gleiss, Adrian C.

Journal:

Year:

2020

File:

PDF, 2.48 MB

2020

25

Horses for courses: reaching outside drug-like chemical space for inhibitors of challenging drug targets

Whitty, Adrian, Zhou, Li

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.80 MB

english, 2015

26

A Study of the Reactivity of S(VI)-F Containing Warheads with Nucleophilic Amino-Acid Side Chains Under Physiological Conditions

Mukherjee, Herschel, Debreczeni, Judit, Breed, Jason, Tentarelli, Sharon, Aquila, Brian, Dowling, James, Whitty, Adrian, Grimster, Neil Patrick

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 3.52 MB

english, 2017

27

Systematic Mutational Mapping of Sites on Human Interferon-β-1a That Are Important for Receptor Binding and Functional Activity

Runkel, Laura, deDios, Carole, Karpusas, Michael, Betzenhauser, Matthew, Muldowney, Celine, Zafari, Mohammad, Benjamin, Christopher D., Miller, Stephan, Hochman, Paula S., Whitty, Adrian

Journal:

Year:

2000

Language:

english

File:

PDF, 513 KB

english, 2000

28

A Direct Binding Assay for the Vascular Cell Adhesion Molecule-1 (VCAM1) Interaction with α4 Integrins

Lobb, Roy R., Antognetti, Giovanna, Pepinsky, R. Blake, Burkly, Linda C., Leone, Diane R., Whitty, Adrian

Journal:

Cell Communication and Adhesion

Year:

1995

Language:

english

File:

PDF, 1.09 MB

english, 1995

29

Progress Towards the Broad Use of Non-Peptide Synthetic Macrocycles in Drug Discovery

Whitty, Adrian, Viarengo, Lauren A., Zhong, Mengqi

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 1.26 MB

english, 2017

30

Critical challenges and emerging paradigms in drug discovery

Adrian Whitty, Michael H Gelb

Journal:

Current Opinion in Chemical Biology

Year:

2010

Language:

english

File:

PDF, 88 KB

english, 2010

31

Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore

Day, Eric S., Capili, Allan D., Borysenko, Christopher W., Zafari, Mohammad, Whitty, Adrian

Journal:

Analytical Biochemistry

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

32

ELISA methods for the analysis of antibody responses induced in multiple sclerosis patients treated with recombinant interferon-β

Margot Brickelmaier, Paula S Hochman, Rem Baciu, Betty Chao, Julio H Cuervo, Adrian Whitty

Journal:

Journal of Immunological Methods

Year:

1999

Language:

english

File:

PDF, 419 KB

english, 1999

33

The Murine Anti-Human Common γ Chain Monoclonal Antibody CP.B8 Blocks the Second Step in the Formation of the Intermediate Affinity IL-2 Receptor

Baker, Darren P., Whitty, Adrian, Zafari, Mohammad R., Olson, Dian L., Hession, Catherine A., Miatkowski, Konrad, Avedissian, Lena S., Foley, Susan F., McKay, Michele L., Benjamin, Christopher D., Bur

Journal:

Year:

1998

Language:

english

File:

PDF, 359 KB

english, 1998

34

Small molecule cytokine mimetics

Adrian Whitty, Christopher W Borysenko

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 1.59 MB

english, 1999

35

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

Singh, Juswinder, Dobrusin, Ellen M., Fry, David W., Haske, Taraneh, Whitty, Adrian, McNamara, Dennis J.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

36

Role of Binding Energy with Coenzyme A in Catalysis by 3-Oxoacid Coenzyme A Transferase

Whitty, Adrian, Fierke, Carol A., Jencks, William P.

Journal:

Year:

1995

Language:

english

File:

PDF, 1.45 MB

english, 1995

37

Comparative Assessment of the Ligand and Metal Ion Binding Properties of Integrins α9β1 and α4β1

Pepinsky, R. Blake, Mumford, Richard A., Chen, Ling Ling, Leone, Diane, Amo, Suzanne E., Riper, Gail Van, Whitty, Adrian, Dolinski, Brian, Lobb, Roy R., Dean, Dennis C., Chang, Linda L., Raab, Conrad

Journal:

Year:

2002

Language:

english

File:

PDF, 245 KB

english, 2002

38

Lessons from Hot Spot Analysis for Fragment-Based Drug Discovery

Hall, David R., Kozakov, Dima, Whitty, Adrian, Vajda, Sandor

Journal:

Trends in Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 2.27 MB

english, 2015

39

Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs

Whitty, Adrian, Zhong, Mengqi, Viarengo, Lauren, Beglov, Dmitri, Hall, David R., Vajda, Sandor

Journal:

Drug Discovery Today

Year:

2016

Language:

english

File:

PDF, 475 KB

english, 2016

40

Thermal performance responses in free-ranging elasmobranchs depend on habitat use and body size

Lear, Karissa O., Whitney, Nicholas M., Morgan, David L., Brewster, Lauran R., Whitty, Jeff M., Poulakis, Gregg R., Scharer, Rachel M., Guttridge, Tristan L., Gleiss, Adrian C.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.13 MB

english, 2019

41

What Is the Fate of Amputee Sawfish?

Morgan, David L., Wueringer, Barbara E., Allen, Mark G., Ebner, Brendan C., Whitty, Jeff M., Gleiss, Adrian C., Beatty, Stephen J.

Journal:

Year:

2016

Language:

english

File:

PDF, 976 KB

english, 2016

42

Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface

Golden, Mary S., Cote, Shaun M., Sayeg, Marianna, Zerbe, Brandon S., Villar, Elizabeth A., Beglov, Dmitri, Sazinsky, Stephen L., Georgiadis, Rosina M., Vajda, Sandor, Kozakov, Dima, Whitty, Adrian

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

43

Mutation of Nonessential Cysteines Shows That the NF-κB Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IκB Kinase-β with High Affinity

Cote, Shaun M., Gilmore, Thomas D., Shaffer, Robert, Weber, Urs, Bollam, Rishitha, Golden, Mary S., Glover, Kimberley, Herscovitch, Melanie, Ennis, Thomas, Allen, Karen N., Whitty, Adrian

Journal:

Year:

2013

Language:

english

File:

PDF, 4.23 MB

english, 2013

44

Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN- α 2b vs. IFN- β 1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor

da Silva, Antonio J., Brickelmaier, Margot, Majeau, Gerard R., Lukashin, Alexander V., Peyman, John, Whitty, Adrian, Hochman, Paula S.

Journal:

Journal of Interferon & Cytokine Research

Year:

2002

Language:

english

File:

PDF, 351 KB

english, 2002

45

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

Michelle R Arkin, Adrian Whitty

Journal:

Current Opinion in Chemical Biology

Year:

2009

Language:

english

File:

PDF, 357 KB

english, 2009

46

Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein–Protein Interfaces

Zerbe, Brandon S., Hall, David R., Vajda, Sandor, Whitty, Adrian, Kozakov, Dima

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 2.24 MB

english, 2012

47

Identification and Characterization of Kava-derived Compounds Mediating TNF-α Suppression

Michael P. Pollastri, Adrian Whitty, Jamie Cassidy Merrill, Xiaoren Tang, Trent D. Ashton, Salomon Amar

Journal:

Chemical Biology & Drug Design

Year:

2009

Language:

english

File:

PDF, 228 KB

english, 2009

48

Selectivity of BAFF/BLyS and APRIL for Binding to the TNF Family Receptors BAFFR/BR3 and BCMA

Day, Eric S., Cachero, Teresa G., Qian, Fang, Sun, Yaping, Wen, Dingyi, Pelletier, Marc, Hsu, Yen-Ming, Whitty, Adrian

Journal:

Year:

2005

Language:

english

File:

PDF, 293 KB

english, 2005

49

Stratification of fertility potential according to cervical mucus symptoms: achieving pregnancy in fertile and infertile couples

Marshell, Marie, Corkill, Marian, Whitty, Mark, Thomas, Adrian, Turner, Joseph

Journal:

Human Fertility: An International, Multidisciplinary Journal dedicated to Furthering Research and Pr

Year:

2019

Language:

english

File:

PDF, 985 KB

english, 2019

50

Interaction Affinity between Cytokine Receptor Components on the Cell Surface

Adrian Whitty, Natalya Raskin, Dian L. Olson, Christopher W. Borysenko, Christine M. Ambrose, Christopher D. Benjamin and Linda C. Burkly

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.42 MB

english, 1998

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